Results
| PMID | 19855902 |
| Gene Name | IL18 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 56 |
| Population details | 56 (34 infertile patients, 22 fertile controls) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Mild endometriosis |
|
Braz J Med Biol Res. 2009 Nov;42(11):1039-43. doi: Glitz, C| Souza, C A| Rodini, G P| Genro, V| Bilibio, J P| Senger, M| Cunha-Filho, J S Departamento de Obstetricia e Ginecologia, Hospital de Clinicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. Interleukin-18 (IL-18) is a cytokine that belongs to the IL-1 family. Endometriosis is strongly associated with sub-fertility, and affects about 15% of women of reproductive age. IL-18 may favor the progression of endometriosis. The objective of the present study was to determine the concentration of IL-18 in the serum and peritoneal fluid of infertile women with endometriosis. Forty infertile and 25 fertile women were screened in a teaching hospital. Thirty-four infertile patients with minimal or mild endometriosis and 22 fertile controls were enrolled in the study. The primary outcome was the estimate of IL-18 levels and the secondary outcome was the correlation between serum and peritoneal levels of IL-18. There were no differences between the two groups regarding age, body mass index and levels of peritoneal fluid IL-18 (mean +/- SD): 290.85 +/- 173.02 pg/mL for infertile women vs 374.21 +/- 330.15 pg/mL for controls; or serum IL-18: 391.07 +/- 119.71 pg/mL for infertile women vs 373.42 +/- 129.11 pg/mL for controls. However, a positive association was found between serum and peritoneal IL-18 levels in patients with endometriosis: r = 0.794, P = 0.0001. All measurements were carried out at the same time by the Human IL-18 Immuno Assay ELISA kit (MBL Co. Ltd., Japan). The present study did not find evidence supporting the hypothesis that IL-18 levels are associated with infertility in women with minimal and mild endometriosis, although a positive correlation was detected in these women between peritoneal and serum levels of IL-18. Mesh Terms: Adult| Ascitic Fluid/*chemistry| Case-Control Studies| Cross-Sectional Studies| Endometriosis/complications/*metabolism| Female| Humans| Infertility, Female/etiology/*metabolism| Interleukin-18/*analysis/blood| Severity of Illness Index|DA 2010/0 |
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